I have found that the first time someone takes colloidal silver, it will virtually act as a drain cleaner. This possibly gives rise to a Herxheimer Reaction, but has the great benefit of reducing the body's bacterial load very substantially.
I have had a headache from colloidal silver if my water intake is not kept reasonably high. colloidal silver seems to act as a diuretic, and can give rise to a dehydration headache resembling a hangover, just like alcohol.